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The quinoline ring contains an amino group at position 5 and a methyl group at position 1 [3]

D-Nle-Cys-Ile-NH-(CH2) 5-CONH2 inhibits B16-F10 murine melanoma cell migration and lung colony formation To evaluate the prospective utility of the 6-AH family members' as potential therapeutics, we examined the capacity of [D-Nle-Cys-Ile-NH-(CH 2 )5~CONH2], an analog that exhibits a strong inhibitory profile against HGF-dependent Met activation, to suppress the migratory and lung colony-forming capacity of B16-F10 murine melanoma cells

Every 10C temperature increase roughly doubles degradation speed

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