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A comparison of copper binding properties, copper exchange rate and redox potential between two similar naturally occurring copper-binding peptides GHK and DAHK shows that even though both bind copper in stoichiometry at a ratio of 1:1, the exchange rate of copper between DAHK peptides is very slow, while the exchange rate between GHK peptides is much faster
It depends on both copper and zinc as cofactors, but only copper regulates its activity ( 2 O 2 , CuZn-SODs activity is suppressed, via oxidation of His-118 to form 2-oxo-histidine (Uchida and Kawakishi, 1994)
doi:10.1523/JNEUROSCI.4489-11.2011 100. Puts, N
For peptide nucleic acids (PNAs), the sugar-phosphate backbone is replaced by a peptide backbone, which retains the specific binding ability with DNA/RNA and offers higher affinity and better stability than natural nucleic acids
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