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In men, HCG is employed to stimulate testosterone production and spermatogenesis in hypogonadotropic hypogonadism (secondary hypogonadism due to pituitary deficiency)

Providers treating transgender patients for gender-affirming hormone therapy should use Z87.890 (Personal history of sex reassignment) as a secondary code while E29.1 remains the primary diagnosis for reimbursement purposes

Treating true deficiency can improve deficiency-related symptoms (including anemia-related fatigue and neurologic issues) (see the NIH ODS Vitamin B12 fact sheet )

The majority of participants were clinically obese adults, though one trial included healthy non-obese volunteers