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We carried out the integration analysis using the top 30 dimensions from a canonical correlation analysis (CCA) based on SCTransform normalized expression of the top 3000 most informative genes across donor datasets, where informativeness was defined by gene dispersion (i.e., the log of the ratio of expression variance to its mean) across cells, calculated after accounting for its relationship with mean expression (using the SelectIntegrationFeatures function)

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Then, in beginning to explain the motivation behind the horrifying deeds he and Dahmer have in common, Nilsen made an observation on the film The Silence of the Lambs, a movie about serial murderers which he has not seen, though he knows the book