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in preclinical models it activates the VEGFR2-Akt-eNOS signaling axis to promote angiogenesis and tissue vascularization ( It also engages ERK1/2 and FAK-paxillin pathways that regulate endothelial cell migration and fibroblast activity, and upregulates heat shock proteins (HSP70/90) for cytoprotective effects in gastrointestinal tissue models ( Research across multiple rodent injury models has characterized its activity in tendon, muscle, nerve, and GI tissue contexts

[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Shimizu S., Kasai S., Yamazaki H., Tatara Y., Mimura J., Engler M.J., Tanji K., Nikaido Y., Inoue T., Suganuma H., et al