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The formalin test was also performed to differentiate its anti-nociceptive effect from an inflammatory reaction or central sensitization

These formulations have different affinities to key proteins and receptors which facilitate the generation of biologically active intracellular cobalamin and thus, differ in their rates of tissue retention and bioavailability ( The formulation and dosage regimens of B12 used to treat Vitamin B12 deficiency vary widely depending on the aetiology of the deficiency as well as region of medical practice (Table 2)

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However, consulting a healthcare provider before starting is strongly recommended