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The role of vitamin B12 and 5-methyl-THF in the conversion of homocysteine to methionine also can have a significant impact on the ability of cells to regenerate the needed active pool of THF derivatives and as such represents the physiologically most significant reaction involving folate

The other pathway is the extrinsic pathway, in which death receptors on the plasma membrane identify and bind special death ligands, inducing apoptosis (32)