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In vitro experiments reveal that GCCNPs could suppress the expression of VEGF in ARPE19 cells and HUVECs induced by H 2 O 2 , inhibit the vascular formation and migration of HUVECs induced by H 2 O 2 , and inhibit the oxidative reaction product 4-HNE and the chemokine stromal-derived factor-1 (SDF-1) and its receptor CXCR4 in laser-induced choroidal neovascularization C57 model mice following intravitreal injection

The Phase 2 retatrutide trial (PMID 37366315) reported -24.2% body weight change at the 12 mg weekly dose across 48 weeks

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