A review of the treatment for increasing NAD + was conducted in this section, with a summary of their biological effects and mechanisms respectively presented in Tables 1, 2, 3 and 4
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Time-course analysis was conducted using two approaches: (i) Hotellings T statistic, combined with a multivariate empirical Bayes method, as implemented in the Timecourse R package [36], and (ii) a composite method based on three polynomial regression models, as implemented in the RolDE R package [37]
