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Although the underlying mechanisms remain poorly understood, these observations emphasize the pivotal role of the kidney-brain axis in neurocognitive dysfunction

~ Genetic variants related to mitochondrial dysfunction and response to stress can show you if you ar more susceptible to depression due to this root cause

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Ultimately, this FOXO4-DRI-mediated mechanism selectively eliminates senescent endothelial cells, which in turn attenuates vascular inflammation and improves endothelial-dependent vasodilation, conferring a significant protective effect on vascular function