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A pathway by which this occurs is suggested in a recent study by Hamdan et al., who found that ROS from human FF of patients with endometriosis damaged mouse oocyte DNA and triggered arrest of meiosis in MI via the DNA damage checkpoint (151)

Evidence that carbonyl stress by methylglyoxal exposure induces DNA damage and spindle aberrations, affects mitochondrial integrity in mammalian oocytes and contributes to oocyte ageing

Another study investigated the potential mechanisms of the Epithalon in influencing gene expression and protein synthesis in stem cells such as gingival mesenchymal stem cells (hGMSCs)

Estrogen improves abnormal norepinephrine-induced vasoconstriction in postmenopausal women