Except for some unusual findings for lung cancer discussed below, associations between elevated serum B12 and increased disease or mortality are most plausibly explained by reverse causation, in which underlying disease raises B12 levels rather than elevated B12 causing disease
In nature, the chemical form cyanocobalamin does not occur and must therefore be transformed in the body in order to take effect
Importantly, the early trials in humans (e.g
GSH depletion In the combination of glutathione and glutathione, the catalytic activity of glutathione-S-transferase and the combination of exogenous chemicals or their metabolites, which can decrease the toxicity and increase the polarity, is one of the most important methods in the biological transformation.When is suitable for the reaction of exogenous chemicals in large doses, may make the depletion of glutathione, a metabolic saturation (metabolic saturation), and in combined with the amount of time no longer increases with the increase of the exogenous chemicals dosage.The corresponding exogenous chemical toxicity, then the dose-response curve with a low dose not, the poison dynamics is characterized by nonlinear dynamics.GSH depletion mixed order is some kind of exogenous chemicals dosage is too large, also can be due to another foreign competition the combination effect of chemicals, or because of undernutrition or tissue damage that glutathione reduced supplies.GSH depletion have any condition that causes can make the original tolerance dose of poison
