However, because of the complexity and diversity of cellular senescence, creating such broadly effective senolytics may be very difficult or even impossible
Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans
Additionally, studies have also found that BSO reduces body weight, BMI, waist-to-hip ratio, liver enzymes, triglycerides, and LDL and total cholesterol
Navitoclax (ABT-263), another inhibitor of the BCL-2 family members, has also been used in many different studies over the years for its ability to eliminate senescent cells by inducing apoptosis