As stated in prior rulemaking (85 FR 58560), generally, the proposed severity level ultimately depends on clinical judgement and, where the data is available, the empirical analysis of the additional resources associated with the secondary diagnosis
doi: 10.1016/j.bbagen.2012.11.020 [DOI] [PubMed] [Google Scholar] 16.Legault J, Carrier C, Petrov P, Renard P, Remacle J, Mirault ME
Yet, the long-term effects of these changes are unknown ( Therefore, more information is needed concerning long-term supplementation, particularly when high doses are used
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