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The clinical diagnosis of obstructive Meibomian gland dysfunction (OMGD) should be considered when the standard, traditional, first line treatment modalities for Meibomian gland dysfunction have failed to provide sufficient relief of symptoms, the patients condition progressively worsens with continued loss of Meibomian glands as seen on meibography, or the patient continues to have recurrent infections of his/her eyelids (styes, hordeola, chalazia, cellulitis, etc.)

Prophylactic oral administration of TB (1 g/kg) could increase portal vein plasma butyrate and improve fatty acid oxidation, thereby alleviating liver injury in endotoxemic rats [105, 106]

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