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This article describes the weight loss efficacy of orforglipron in adults with obesity

This capacity of FcRn antagonists to modulate the pharmacokinetics of other IgG-based Ab therapeutics was investigated in a phase I clinical trial (NCT04973566) addressing the effect of nipocalimab on the pharmacokinetics of the IgG Fc-fusion etanercept, which consists of the extracellular domains of tumor necrosis factor-alpha receptor 2 fused to an IgG1 Fc

Interestingly, we consistently observed downregulation of RRM2 at the protein level across all single and combination treatments

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