(2) dissociation of tumor cells from the primary tumor mass, (3) invasion of the neighboring tissue, (4) intravasation into pre-existing and newly formed blood and lymph vessels, (5) transport through the vessels, (6) extravasation from the vessels, (7) establishment of circulating tumor cells (CTCs) and the disseminated cells at a secondary anatomical site, where they can stay dormant for a prolonged period of time, (8) metastatic outgrowth of micrometastases and macrometastases creating clinically detectable secondary tumors and neoplastic process [13]
In that context, it is noteworthy that optimal function of stem cells depends on their highly specialized microenvironment, or niche [30, 31], and SASP factors deleteriously affect stem cells by altering this niche [32, 33]
Jonathan Willbanks what's the thinking on oral vs injected for someone just dealing with gut issues
I think we can safely say the overwhelming answer would be (b)