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Accordingly, there is interaction with many molecular pathways, combining maintained endothelium function and maintained thrombocytes function, which counteracted thrombocytopenia in rats that underwent major vessel occlusion and deep vein thrombosis and counteracted thrombosis in all vascular studies

[8] Each individual B vitamin is water-soluble and generally very safe at physiologic doses, but the combination product should only be used when clearly needed

This is a side effect that appears repeatedly in the clinical literature and is reliably absent from forum discussions until it happens to a new user, who then reports it with considerable alarm