The expression of constitutively active, standard immunotherapy treatment (trastuzumab and pertuzumab) resistant, truncated p95-ErbB2 in breast cancer cells activates macropinocytosis leading to increased uptake of extracellular cholesterol
Byrne JJ, Soh MS, Chandhok G, Vijayaraghavan T, Teoh JS, Crawford S, Cobham AE, Yapa NMB, Mirth CK, Neumann B (2019) Disruption of mitochondrial dynamics affects behaviour and lifespan in Caenorhabditis elegans
Generally speaking, were looking at a hyperactive sympathetic (fight or flight) response and an underactive parasympathetic (rest and digest) response
This result is consistent with data obtained by the hematology analyzer, showing cell swelling, and describes the morphology of slow RBCs, discovered by transport analysis in microfluidic channels