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No pharmaceutical company, no academic medical center, and no government agency has found the existing preclinical data compelling enough to fund a rigorous human trial in over 30 years

This type of cochlear synaptopathy, referred to as hidden hearing loss because the deficits can hide behind a normal audiogram 11 , is posited to trigger neural hyperactivity that underlies tinnitus 19,20,21 , potentially offering a valuable drug target for the development of novel tinnitus treatments

Many Hsps are currently being considered for the potential treatment of diseases involving protein aggregation and misfolding such as the case of PD [116,118]

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