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1973 IARC Monographs on the Carcinogenic Risk of Chemicals to Man

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Stuart King James I wrote a famous polemic titled A Counterblaste to Tobacco in 1604, in which the king denounced tobacco use as [a] custome lothsome to the eye, hatefull to the Nose, harmefull to the braine, dangerous to the Lungs, and in the blacke stinking fume thereof, neerest resembling the horrible Stigian smoke of the pit that is bottomelesse . [9] That year, an English statute was enacted that placed a heavy protective tariff on tobacco imports

Hiccups or nausea caused by excess saliva or swallowing small amounts of nicotine