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The peptide suppresses appetite and modulates glucose metabolism, but outcomes depend heavily on the broader context of diet and activity

Notably, ketoconazole abolished low-density lipoprotein (LDL)-induced reductase activity at submicromolar concentrations in various mammalian cell lines (IEC-6 cells, skin fibroblasts, HepG2, and Chinese hamster ovary cells), suggesting a potential application in cardiovascular disease [99]

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Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation