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Because NNMT occupies a central position within nicotinamide methylation pathways, it has become an important target for investigations involving enzyme regulation, methyl-donor utilization, cofactor-associated signaling networks, and methyltransferase pharmacology

NNMT and Cancer Elevated NNMT expression has been observed in several forms of cancer, including gastric, pancreatic, renal cell carcinoma, and bladder cancers

Athletes subject to WADA, USADA, NCAA, or other sport-governing-body testing should not use it

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