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PROBOLINGGO, Indonesia - Thirteen-year-old Siti Maryam says she suffers headaches and nausea after harvesting tobacco leaves with her bare hands during four years of working on her family's farm in Indonesia

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The effects of tobacco smoke on DC biology, especially its strong adjuvant potential on the subepithelial DC network, suggest that an aberrant DC function might underlie the allergic sensitization observed toward concurrently inhaled antigens during smoking