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Acknowledgements The National Natural Science Foundation of China (82073144, J.W.), the Health Commission of Zhejiang Province (JBZX-202004, J.W.), the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (LHDMD22H310005, J.W.)

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Functional Assessments Range of motion testing measured with a goniometer at consistent intervals (weekly) Pain scales standardized VAS (visual analog scale) scores, recorded at the same time of day Strength testing grip strength, manual muscle testing, or machine-based measurement Gait analysis for lower extremity injuries, tracking stride length and symmetry GI symptom diaries for gut-related applications, daily tracking of symptoms (bloating, pain, stool quality) Biomarkers CRP (C-reactive protein) systemic inflammation marker