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Dietary folate deficiencies and drugs that interfere with folate metabolism, eg, methotrexate, an anti-carcinogenic agent that inhibits dihydrofolate reductase, and nitrous dioxide (N 2 O), an anesthetic gas that inhibits methionine synthase activity, lead to accumulations and cellular effluxes of homocysteine, causing increases in circulating homocysteine levels (Ueland and Refsum, 1989)

Glutathione is the bodys most abundant, natural anti-oxidant which is produced in the liver to help us rid our body of toxins

It remains unclear whether a loading dose is necessary for rapid treatment of vitamin B12 deficiency via intranasal administration

Reconstitute according to validated protocols