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Longer sessions require more clinician time and monitoring

Activation of IGF-IR triggers multiple signaling cascades in a cell context-dependent manner to regulate diverse cell functions ranging from proliferation and survival to differentiation into specialized cell lineages

By reframing neuroprotection as a systemic, multicellular endeavor, this review highlights the potential to not only extend life expectancy, but also preserve meaningful quality of life in individuals affected by neurodegenerative diseases