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Systematic reviews and comparative PK studies confirm that specialized curcumin preparations can increase systemic exposure versus unformulated curcumin, but the magnitude of the increase depends strongly on formulation type, dose, and the analytic method used to quantify free versus conjugated curcuminoids

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Identity, measured content and contaminant testing address different questions and should be considered separately

However, direct binding of copper to lipoylated DLAT has been observed, resulting in protein oligomerization during cuproptosis (Tsvetkov et al., 2022)