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This cellular damage activates hepatic stellate cells (HSCs), which are key players in liver fibrogenesis, contributing to the deposition of extracellular matrix proteins and the progression of fibrosis [8,9,10]

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In a randomized crossover trial comparing healthy subjects who smoked tobacco (maximum of 10 cigarettes per month), the acute use of nicotine-containing e-cigarettes significantly increased levels of circulating endothelial progenitor cells (flow cytometry) to the same magnitude as after smoking a traditional cigarette (41)

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