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Despite the previously observed facilitated uptake of 5-(3,4-dihydroxyphenyl)--valerolactone into blood cells ( 5.3 Distribution into endothelial cells The vascular endothelium plays an essential role in cardiovascular health (65) and binding and/or uptake of dietary polyphenols to endothelial cells presumably contributes to beneficial health effects

This risk is quite shocking since, according to the Tylenol website: The National Kidney Foundation recommends acetaminophen, the active ingredient in TYLENOL, as the pain reliever of choice for occasional use in patients that have underlying kidney disease (27). Yet, according to Moffitt Cancer Center: Now acetaminophen is making headlines because California regulators are considering labeling it a carcinogen