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In particular, germinal center (GC) B cells, composed of activated B cells, abundantly produced intracellular ROS, which was further elevated by LBI feeding (Fig

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doi: 10.3389/fpls.2014.00662 Received 26 September 2014 Accepted 06 November 2014 Published 21 November 2014 Volume 5 - 2014 Edited by Dibyendu Talukdar, Raja Peary Mohan College (Affiliated to University of Calcutta), India Reviewed by Dibyendu Talukdar, Raja Peary Mohan College (Affiliated to University of Calcutta), India

It is known that, in rat and human GLCL holoenzyme, cystamine completely inactivates rat GLCL activity by interaction with a thiol group that is thought to be at or near the l-glutamate-binding site in the wild enzyme [135,136,137,138] and also in a recombinant mutant (hGLCLC-C553G) where one cysteine group far from the active site was selectively inactivated [139]