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FIGURE 5 4.4 Epigenetic regulation of drug resistance In the epigenetic regulatory network of gemcitabine resistance, long noncoding RNA (lncRNA) mediated RRM2 regulation and dynamic regulation of drug-metabolizing enzymes by m 6 A (N6-methyladenosine) methylation modification are two key mechanisms that together constitute a complex resistance network: In the mechanism of gemcitabine resistance, oncogenic lncRNAs (such as MALAT1 and NEAT1) significantly promote the expression of ribonucleotide reductase M2 (RRM2) through epigenetic regulation (Wang et al., 2021)

Madhu, Kaur A, Singh K, Upadhyay SK (2024a) Ascorbate oxidases in bread wheat: gene regulatory network, transcripts profiling, and interaction analyses provide insight into their role in plant development and stress response

At this point, having eliminated the danger caused by free radicals, glutathione can regain its antioxidant activity and return to its reduced form