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First, a bacterial reverse mutation test (Ames test) assessed AOD9604s mutagenic potential using four histidine-dependent auxotrophic mutants of Salmonella typhimurium (TA1535, TA1537, TA98, TA100) and one tryptophan-dependent auxotrophic mutant of Escherichia coli (WP2 uvrA), using both plate incorporation and pre-incubation methods at doses of 0, 1.6, 8, 40, 200, 1,000, and 2,000 g AOD9604/plate
Most available evidence comes from laboratory and animal studies, where researchers have observed potential effects on: Tendon healing Ligament repair Muscle recovery Gastrointestinal tissue repair Angiogenesis Inflammatory signaling Although these findings are promising, robust human clinical trials remain limited
J Pharmacol Exp Ther (2011) 339:3544 10.1124/jpet.111.182220 [DOI] [PMC free article] [PubMed] [Google Scholar] 134.Kawas LH, Yamamoto BJ, Wright JW, Harding JW