Bischoff-Ferrari HA, Gngler S, Wieczorek M, Belsky DW, Ryan J, Kressig RW, Sthelin HB, Theiler R, Dawson-Hughes B, Rizzoli R, Vellas B, Rouch L, Guyonnet S, Egli A, Orav EJ, Willett W, Horvath S (2025) Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
That's why most research protocols build in a break between cycles, often called a washout period, to let the body reset before starting again
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