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Hormonal changes: Conditions like melasma are linked to hormonal changes and often occur during pregnancy or when using birth control pills
SLC7A11, a key FRG in pan-RCC and a major functional subunit of the system X c , which participates in cysteine transport and inhibits cellular ferroptosis by participating in GSH synthesis, seems to have opposite effects on the regulation of disulfidptosis and ferroptosis, and further exploration of both of these effects is needed (185)
This System Xc /GSHGPX4 axis is thus a major ferroptosis pathway, with direct relevance to renal I/R injury