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Notably, oxidative phosphorylation efficiency at complexes I and IIspecifically when glucose was the fuel sourceemerged as a stronger predictor of GWS severity than markers of peripheral inflammation

McQueen T, Konopleva M, Andreeff M

Just that we have very limited data on the systemic effects

The variations in ROS generation could affect the amounts of oxidized proteins, lipids, and DNA damage, increasing the colons vulnerability to GI disorders at these two intestinal sites (129)