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Keywords: Ulcerative colitis, Smoking status, Casecontrol study, Meta-analysis Subject terms: Environmental sciences, Environmental social sciences, Diseases, Gastroenterology Introduction Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterised by chronic, non-specific, and recurrent disease 1 that affects the mucosal layers of the colon (large intestine) and, to a lesser extent, the rectum 2

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M2a microglia exhibit significant phagocytic activity and respond to IL-4 and IL-13 stimulation by producing an insulin-like growth factor-1, anti-inflammatory cytokines such as IL-10