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According to StatPearls (NCBI Bookshelf), the most common adverse effect of intramuscular vitamin B12 injections is significant pain at the injection site, which is particularly noted in thinner individuals

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Combination of low concentrations of bone morphogenic protein (BMP), high concentrations of Nodal/Activin A, and Wnt/-catenin signaling generates definitive endoderm (DE) (Pour et al., 2022)