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The BPRF is defined as the 5th (if harmful) or 95th (if protective) quantile estimate of the risk closest to the null estimate, with the 5th quantile reflecting the smallest harmful effect of a risk exposure on a given health outcome that is consistent with the available evidence

Food and Drug Administration HPHCs: Harmful and Potentially Harmful Constituents HINTS: Health Information National Trends Survey NNN: N -Nitrosonornicotine NNK: Nicotine-derived nitrosamine ketone NRT: Nicotine replacement therapy PMI: Philip Morris International References Reitsma MB, Kendrick PJ, Ababneh E, Abbafati C, Abbasi-Kangevari M, Abdoli A, et al

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