Outcome measures cover histological damage scoring, cytokine panels (TNF-, IL-6, IL-10), mucosal blood flow, tight junction protein expression by Western blot, and stool consistency scoring for colitis models
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Regulatory and Compliance Risk : The Food and Drug Administration (FDA) classified BPC-157 under Category 2 in 2023, prohibiting its legal compounding due to insufficient safety data
In 1993, Sikiric and colleagues in Zagreb isolated a cytoprotective protein from human gastric juice, called Body Protection Compound (BPC), whose fragment 157 (15 amino acids) reproduces most of its regenerative activity