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A concentration of 50 mol/L artesunate selectively induces cell death in head and neck cancer cells without affecting normal cells by activating an iron-dependent, ROS-accumulating ferroptosis pathway [139]

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[PubMed: 24810749] (14 year old girl took an intentional overdose of 10 tablets of ALA [6000 mg] and rapidly developed convulsions with metabolic acidosis [pH 6.5, lactate 24 mmoL] progressing to multiorgan failure and dying within 19 hours of admission [platelets 114,000 to 12,000/L, INR 2.8 to 6 .0, creatinine 1.2 to 2.2 mg/dL, CK 1,059 to 18,383 U/L, ALT 43 to 76 U/L])