It was initially shown that in drug addicts, who were accidentally exposed to MPTP, there was a depletion of pigmented nerve cells in the substantia nigra, accompanied by astrogliosis and clustering of microgliosis around nerve cells [41], thus presenting some PD-like features
GSH is exclusively degraded at the extracellular level by cells expressing -glutamyltranspeptidase (GGT), such as those of the hepatobiliary tree and of other organs like the heart, kidney, lungs, pancreas, and seminal vesicles
An increase in intracellular glutamate associated with a decrease in NAA may be specific to ALS, as it has not been consistently reported in other neurodegenerative diseases that are accompanied by a decrease in NAA levels
The collected platelets are then injected back into the injured area to stimulate healing and regeneration