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Moreover, local intracellular accumulation and receptor-independent actions may require higher pharmacological concentrations of melatonin to engage redox-sensitive pathways such as NRF2 compared with approaches which target the central nervous system

Contaminated DNA was removed with a purifying column

Piglets in the LPS-treated groups were intraperitoneally injected with Escherichia coli LPS (Escherichia coli serotype 055: B5, Sigma Chemical Inc., St

Rather than being investigated within a single biological pathway, it has featured in laboratory studies examining molecular signalling, extracellular matrix biology and the complex interactions that influence normal tissue organisation