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The polyphenol extract of Ajwa dates reduced oxidative stress and improved antioxidant enzyme activity in hypercholesterolemic rats [36]

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The glutamate-induced persistent depolarization affects mitochondrial membrane polarization, impairing mitochondrial function and energy metabolism (see section Oxidative stress and redox imbalance in the CNS, and [91])

These are complementary strategies that address weight through different biological pathways -- CagriSema through dual appetite suppression mechanisms, retatrutide through appetite suppression plus increased energy expenditure