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The varenicline and placebo cohorts comprised 52.0% and 53.0% women, aged mean 51.6 (SD, 11.9) and 52.4 (SD, 11.0) years, they smoked 12.9 (SD, 6.9) and 12.2 (SD, 6.2) cigarettes per day, 16.0% and 17.5% used other types of tobacco, 87.7% and 83.0% smoked menthol cigarettes, and 79.0% and 83.5% had attempted to quit in the past year, respectively

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(1) uninfected macrophages express anti-inflammatory responses, including polarization of CD206 + M2 macrophages and increased expression of IL10, whereas (2) infected macrophages show inflammatory responses, including differentiation to M1 macrophages and increased expression of iNOS, TNF-, and IL6