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Here are some of the drugs shown to affect melatonin: Antidepressants including Fluoxetine (Prozac), Paroxetine (Paxil), Sertraline (Zoloft), Citalopram (Celexa), Escitalopram (Lexapro), Venlafaxine (Effexor) Benzodiazepines including Diazepam (Valium), clorazepate (Tranxene), lorazepam (Ativan), Clonazepam (Klonopin), Alprazolam (Xanax) Antipsychotics including Aripiprazole (Abilify), Quetiapine (Seroquel), Risperidone (Risperdal), Olanzapine (Zyrexa), Haloperidol (Haldol), Paliperidone (Invega), Ziprasidone (Geodon) If you take one of these drugs, you should consider supplementing with melatonin every night

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A study in the International Journal of Dermatology revealed that combining oral PLE with sunscreen achieved a greater reduction in melasma severity than sunscreen alone