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doi: 10.1016/j.biomaterials.2022.121930 160 MurphyCLalorSJLynchMAMillsKHG

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However, the challenges for viral-mediated approaches are some of the largest in the clinical trial setting: the inflammatory response to viral particles, the tissue-unspecific uptake of the content, the lack of entry in target cells, oncogenic side effects, and the overall absence of effect in most clinical trials carried out are some of the aspects that make these types of approaches hard to implement [285,286,287,288]