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Given that Italian smoking prevalence was about 35% at the time, one can imagine that Italys 18 million or so smokers corresponded more or less with the population that either doubted the risk of smoking or felt reassured by filters and light cigarettes

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Accordingly, changes in metabolite levels resulting from gut flora dysbiosis make an unavoidable effect on CNS, releasing fear- or anxiety-like emotions or triggering depression, subsequently elevating the risk of smoking initiation or failure to smoking cessation [73,74,75]