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In mouse oocytes, Epitalon significantly reduced levels of H2AX, a marker of DNA double-strand breaks, and prevented apoptosis [46]

While constantly exposed to self-generated lactate, their intracellular lactylation landscape may be tuned for homeostatic feedback regulation, perhaps modifying glycolytic enzymes or proteins involved in the astrocyte-neuron lactate shuttle to maintain metabolic coupling (Zhou et al., 2024)

When the above concerns are addressed along with the safety and efficacy of nanozyme-hydrogels, they can be freely used in patients to treat chronic wounds in real-world applications [189]

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