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21 Insulin-like growth factor-1 (IGF-1) is the leading anabolic growth factor in cartilage and is important for structural maintenance via stimulation of cartilage matrix molecules

Benefits include improved skin health and brightness, enhanced immune function, reduced oxidative stress, detoxification of the liver, and anti-aging effects

Melatonin and NAC have been evaluated in several human studies, particularly in patients undergoing ART, and demonstrate moderate clinical support for improving oocyte quality and fertilization outcomes

While some immune functions (DNA synthesis) are favored by high GSH levels, certain signal pathways are enhanced by oxidative conditions and lower intracellular glutathione concentrations, indicating that GSH operates as a bidirectional immunomodulator rather than a simple immunostimulant